Document Details

Document Type : Thesis 
Document Title :
Optimizing Vancomycin Use in Patient with Hematological Malignancy with/without Febrile Neutropenia
الاستخدام الأمثل للفانكومايسن في مرضى اورام الدم الخبيثة مع او بدون حمى نقص كريات الدم البيضاء
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Background and Objectives: Vancomycin administration in individuals with hematological malignancy (HM) or neutropenia is associated with suboptimal trough concentration. Nonetheless, most studies did not distinguish whether the low vancomycin trough concentration was due to HM or neutropenia. Furthermore, little research has been done to assess the effect of FN on AUC0-24 and pharmacokinetics parameters. This study aimed to determine the association the type of HMs, and FN with low vancomycin trough concentration and to assess the effect of FN on AUC0-24 as a key parameter for vancomycin monitoring, as well as to determine which vancomycin PK parameters are affected by the presence of FN using Bayesian software PrecisePK in a neutropenic patient with HMs. Materials and Methods: The present retrospective chart review study was conducted using clinical data adopted from CPOE (BestCare®) for all patients who received intravenous vancomycin treatment between 2017 till 2020 at the King Abdulaziz medical city in Jeddah (KAMC-J). Results: Out of the 296 patients, 217 were included. There was no significant association between the type of HM and the incidence of the low trough concentration; p>0.05. At the same time, a significant association between FN and the incidence of the low trough concentration was observed (p<0.05). In addition, there is a significant association between febrile neutropenia and augmented renal clearance (ARC) (p<0.05). Another important finding is that FN has a substantial effect on vancomycin AUC0-24, and this effect may be aggravated in the presence of ARC concurrently. Additionally, the FN has a potential effect on the vancomycin clearance, Vdss, Vdp, t½β, K12 and K10. Conclusion: The findings of this study conclude that FN was associated with low vancomycin concentrations and AUC0-24. Interestingly, ARC was observed in most of the FN patients with a significant association that might be considered the main driver for the low trough in neutropenic patients. “ 
Supervisor : Dr. Shahid Karim 
Thesis Type : Master Thesis 
Publishing Year : 1444 AH
2023 AD 
Co-Supervisor : Prof. Dr. Ahmed S. Ali 
Added Date : Tuesday, March 7, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالله محمد الزهرانيAlzahrani, Abdullah MohammedResearcherMaster 

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