Faculty of Computing and Information Technology in Rabigh | Researches | Identification of hub genes and their SNP analysis in West Nile virus infection for designing therapeutic methodologies using RNA-Seq data.

Faculty of Computing and Information Technology in Rabigh

Document Details

Document Type	:	Article In Journal
Document Title	:	Identification of hub genes and their SNP analysis in West Nile virus infection for designing therapeutic methodologies using RNA-Seq data. تحديد الجينات محور وتحليل الحزب الوطني الاسكتلندي في عدوى فيروس غرب النيل لتصميم منهجيات العلاجية باستخدام بيانات الحمض النووي الريبي يليها
Subject	:	Bioinformatics
Document Language	:	English
Abstract	:	The West Nile virus (WNV) infections are generally asymptomatic and are considered as immediate concerns of biodefense due to the lack of any therapeutic remedies. In this work, we created an interaction network of 1159 differentially expressed genes to detect potential hub genes from WNV infected primary human macrophages. We go on to explore the genetic variations that can alter the expression and function of identified hub genes (HCLS1, SLC15A3, HCK, and LY96) using the PROVEAN Protein Batch tool and PolyPhen-2. Community analysis of the network revealed that these clusters were enriched in GO terms such as inflammatory response and regulation of proliferation. Analysis of hub genes can aid in determining their degree of conservation and may help us in understanding their functional roles in biological systems. The nsSNPs proposed in this work may be further targeted.
ISSN	:	1976-9571
Journal Name	:	GENES and GENOMICS
Volume	:	37
Issue Number	:	8
Publishing Year	:	1436 AH 2015 AD
Article Type	:	Article
Added Date	:	Monday, February 29, 2016

Researchers

Researcher Name (Arabic)	Researcher Name (English)	Researcher Type	Dr Grade	Email
افتخار اسلام طيوبي	Tayubi, Iftikhar Asalm	Investigator	Doctorate	Iftikhar.tayubi@gmail.com

Files

File Name	Type	Description
38305.pdf	pdf

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