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Document Type |
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Thesis |
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Document Title |
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Vitamin D status in postmenopausal Saudi women with type 2 diabetes mellitus حالة فيتامين د لدى النساء السعوديات بعد سن اليآس المصابات بمرض السكري من النوع الثاني |
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Subject |
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Biochemistry department |
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Document Language |
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Arabic |
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Abstract |
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Vitamin D is involved in glucose homeostasis and in the mechanisms underlying insulin release. Vitamin D deficiency increases the risk of many diseases, including type 2 diabetes and osteoporosis. Serum 25-hydroxy vitamin D (25-OHD) an important determinant of bone health. This study assessed vitamin D status in postmenopausal diabetic and non-diabetic Saudi women and determined the incidence of low bone mineral density (BMD) in relation to body mass index (BMI) and bone turnover markers (BTMs). Postmenopausal Saudi women (n 98) aged 50–75 years living in Jeddah, Saudi Arabia were divided into diabetic (n=53) and non-diabetic (n=45) groups. Serum25-OHD, levels of intact parathyroid hormone (iPTH), glucose, insulin and BTMs were measured. BMD was measured by dual-energy X-ray absorptiometry (DXA) at the lumbar spine, total hip and femur neck. We observed that 86.9% of the diabetic group and 82.3% of the non-diabetic group were vitamin D-deficient [25-OHD<50.0 nmol/L (20 ng/ml)]. The prevalence of osteoporosis was 7.7% in the diabetic group and 13.6% in the non-diabetic group at the lumbar spine and was 13.5% in the diabetic group and 0% in the non-diabetic group at the femur neck. The women were further divided into four subgroups according to their diabetes diagnosis and BMI: subgroup i, 35 diabetic obese; subgroup ii, 18 diabetic overweight; subgroup iii, 25 non-diabetics obese; and subgroup iv, 20 non-diabetics overweight. A serum 25-OHD level was inversely related to BMI at diabetic subgroup and PTH in all four subgroups. BMI was significantly positively correlated with BMD at lumbar spine in non-diabetic obese subgroup and was negatively correlated with BMD at three sites in the diabetic obese subgroup. Markers of diabetes mellitus [insulin, glucose and homeostatic model assessment-insulin resistance (HOMA-IR) were negatively correlated with 25-OHD in the diabetic overweight subgroup compared to the non-diabetic obese subgroup. The 25-OHD level was significantly positively associated with BMD at the lumbar spine in the non-diabetic obese subgroup. Markers of bone turnover (osteocalcin (OC) and C-terminal telopeptide (CTx)) were significantly negatively correlated with 25-OHD in both the diabetic and non-diabetic overweight subgroups. A significant negative correlation was observed between OC and s-GLU at diabetic obese women. At non-diabetic obese a significant positive correlation was observed between CTX and s-GLU. The diabetic obese women had a slightly higher mean BMD value than the non-diabetic. Our findings suggest that, BTMs were decreased, this low BTMs can slow bone loss rate and causes higher bone density. The decrease in BTMs level could also increase skeletal fragility. The BMD results suggested that osteoporosis was more common among these diabetic women at femur neck and certainly warrants further investigation. In conclusion, low vitamin D levels contribute to osteoporosis and diabetes mellitus in postmenopausal Saudi women. |
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Supervisor |
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Dr. Sawsan Omer Khojah |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1433 AH
2012 AD |
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Co-Supervisor |
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Prof. Mohammad-Salleh Mohammad Ardawi |
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Added Date |
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Wednesday, June 13, 2012 |
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Researchers
| سلمى يحي صديق | Saddekk, Salma Yahay | Researcher | Master | |
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