Document Details Document Type : Article In Journal  Document Title : IMMUNOLOGIC PATTERNS OF PATIENTS WITH NON-CANCEROUS THYROID LESIONS IMMUNOLOGIC PATTERNS OF PATIENTS WITH NON-CANCEROUS THYROID LESIONS   Document Language : English  Abstract : Objectives: The present study was designed to determine T helper-1/T helper-2 (Th1/Th2) pattern in patients with Graves' disease (GD), benign multinodular goiter (MNG) and Hashimoto thyroiditis (HT). Patients & Methods: The study included 75 patients (56 females and 19 males; with mean age of 43.8±8.2 years) with thyroid swelling, 43 patients with GD, 17 patients had MNG and the remaining 15 patients had HT and 15 healthy volunteers with mean age of 42.7±13 (control group). The study group underwent clinical examination, laboratory investigations and thyroid ultrasound .Patients with HT received medical treatment and were followed-up, while patients with GD and MNG underwent thyroidectomy. Blood samples were collected from patients and control subjects for ELISA estimation of serum levels of interleukin-2 (IL-2), IL-18, IL-4 and IL-5. Results. Mean serum levels of IL-2, IL-4 and IL-5 were significantly higher in patients compared to control levels irrespective of the type of thyroid lesion. Mean serum levels of IL-18 were significantly higher in patients with HT and MNG disease and non-significantly higher in patients with GD compared to control levels. Moreover, mean serum levels of IL-2 and IL-18 were significantly higher and mean serum levels of IL-5 were significantly lower in patients with HT and MNG disease compared to those with GD and in HT patients compared to those with MNG . Also, mean serum levels of IL-4 were significantly lower in patients with HT and MNG disease compared to those with GD with a non-significant decrease in patients with HT compared to those with MNG disease. Conclusion: It could be concluded that there was a disturbed pattern of Th1/Th2 cytokines in patients with non-cancerous thyroid lesion in favor of humoral pattern of immune response in GD with predominance of Th2 cytokines and a Th1-pattern of immune response characteristic of cellular immunity is dominant in HT.  ISSN : 1110-1431  Journal Name : Zagazig university medical journal  Volume : 13  Issue Number : 6  Publishing Year : 2007 AH 2007 AD  Article Type : Article  Added Date : Saturday, May 15, 2010  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email أسامة جابر Gaber, Osama Researcher Doctorate   Files File Name Type Description  26668.doc doc   Back To Researches Page