Document Details Document Type : Article In Journal  Document Title : Vitamin D deficiency in SLE patients. نقص مستوى فيتامين د لدى المرضى السعوديين المصابين بمرض الذئبة الحمراء   Subject : determination of vitamin D status among Saudi patients with SLE versus matched control group.  Document Language : English  Abstract : Background: An association between vitamin D deficiency and the development of systemic lupus erythematosus (SLE) has been suggested. Aims: This study was conducted to determination of vitamin D status among Saudi patients with SLE versus matched control group. Methods: Hospital-based cohorts of 165 SLE patients and 214 SLE-free volunteers were recruited at King Abdulaziz University Hospital in Jeddah, Kingdom of Saudi Arabia. Serum levels of 25-hydroxyvitamin D [25(OH)D] were measured. Serum levels of 25(OH)D < 50nmol/L (< 20ng/ml), levels >50 - <75nmol/L (>20-<30ng/ml) and levels <75nmol/L (<30ng/ml) were used as the cut-off values for vitamin D deficiency, insufficiency and inadequacy, respectively. Results: The prevalence of SLE patients with 25(OH) D inadequacy and deficiency was significantly higher than that in control group: 98.8 vs. 55%, 89.7 vs. 20% (p <0.0001). Only two (1.2%) SLE patients had adequate levels of 25(OH)D compared to 96 (45%) of control group (p<0.0001). The mean serum levels (nmol/L) of 25(OH)D in SLE patients with vitamin D inadequacy and deficiency in comparison to control group were 22.3 + 13.6 vs. 44.5 + 17.5 (p<0.0001) and 19.1 + 9.5 vs. 22.9 + 6.7 (p=0.0152), respectively. No significant differences were evident with respect to the mean serum levels of 25(OH)D and prevalence of its deficiency in female and male patients with SLE. Conclusions: Vitamin D inadequacy is highly prevalent in Saudi patients with SLE. Vitamin D supplementation, and further evaluation of its subsequent role in the prevention and/or treatment of SLE is needed.  ISSN : 16583175  Journal Name : Medical Saudi Journal  Volume : 30  Issue Number : 10  Publishing Year : 1430 AH 2009 AD  Article Type : Article  Added Date : Tuesday, May 11, 2010  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email ليلى حامد دمنهوري لا يوجد لا يوجد No, Laila H. Damanhouri No Investigator Doctorate lhhd71@hotmail.com Files File Name Type Description  26652.doc doc relation between vitamin D and SLE diseas in Saudi patients, which was found low. Back To Researches Page